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Abstract—The profile of globoidal indexing cam is spatial undevelopable surface. It needs special CNC machine tool to finish batch production. The machining quality of the profile of globoidal indexing cam could be affected by the movement error of each part of machine tool and the clamped positioning error of workpiece. Firstly，this paper analyses the systematic error of the special machine tool of globoidal cam, derives the error transfer matrix, establishes the mathematical model of the globoidal cam profile which including all machining system errors through multi-body system theory primarily. Secondly, it analyzes the influence caused by each machine tool error and calculates the influence coefficient of machine tool errors. Finally, it simulates the influence of each error on the transmission accuracy of globoidal cam mechanism. This paper lays a theoretical foundation for the distribution of machine errors and the error detection, the error evaluation and the error tracing of globoidal cam profile.